Putative biological predictors of treatment response in bipolar disorders

http://dx.doi.org/10.1016/j.pmip.2016.11.003 2468-1717/ 2016 Elsevier Inc. All rights reserved. Abbreviations: BD, bipolar disorder; CSF, cerebrospinal fluid; BDNF, brain-derived neurotrophic factor; NT3, neurotrophin-3; NT4, neurotrophin-4; NGF, nerve factor; Trk, tyrosine kinase receptor; p75, TNF receptor superfamily member 1B; CNS, central nervous system; MDD, major depressive disorder; DLPFC, dorsolateral p cortex; ECT, electroconvulsive therapy; GDNF, glial-derived growth factor; TGFb, transforming growth factor beta; VEGFA, vascular endothelial growth factor A fibroblast growth factor 2; IGF-1, insulin-like growth factor 1; BMPs, bone morphogenic proteins; MRS, magnetic resonance spectroscopy; ETC, electron transpo iPSCs, induced pluripotent stem cells; PFC, prefrontal cortex; TBARS, thiobarbituric acid reactive substances; NO, nitric oxide; SOD, superoxide dismutase; glutathione peroxidase; IL, interleukin; TNF, tumor necrosis factor; IFN-c, interferon-gamma; sIL-2R, soluble IL-2 receptor; sIL-6R, soluble IL-6 receptor; CRP, C protein; TFN, transferrin; HPA, hypothalamicpituitaryadrenal; CRH, corticotropin-releasing hormone; ACTH, adrenocorticotrophic hormone; GR, glucocorticoid re DST, dexamethasone suppression test; Dex, dexamethasone; FKBP5, FK506 binding protein 5; BAG1, BCL2 associated athanogene 1; PTGES3, prostaglandin E syn HSP70, heat shock protein 70; TSH, thyroid-stimulating hormone; T4, thyroxine; TRH, thyrotropin-releasing hormone; PFDN4, prefoldin subunit 4; DPY19L2P2, pseudogene 2; PCMT1, protein-L-isoaspartate (D-aspartate) O-methyltransferase; ICE1, interactor of little elongation complex ELL subunit 1; RNMT, RNA g methyltransferase; SS18, SS18, nBAF chromatin remodeling complex subunit; NF1, neurofibromin 1; SLC35D1, solute carrier family 35 member D1; E2F4, E2F tran factor 4; PIK3CD, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; MTF1, metal regulatory transcription factor 1; FAM21A/B/C/D, family with s similarity 21 member A/B/C/D; VAMP3, vesicle associated membrane protein 3; C9orf16, chromosome 9 open reading frame 16; IKBKG, inhibitor of kappa light pol gene enhancer in B-cells, kinase gamma; STX11, syntaxin 11; PSMD1, proteasome 26S subunit, non-ATPase 1; Plec, plectin; SPR, sepiapterin reductase; MAPK6, m activated protein kinase 6; CCL2, CC motif chemokine ligand 2; PTX3, pentraxin 3; EMP1, epithelial membrane protein 1; BCL2A1, BCL2 related protein A1 phosphodiesterase 4B; IL1B, interleukin 1 beta; IL6, interleukin 6; TNFAIP3, TNF alpha induced protein 3; PTGS2, prostaglandin-endoperoxide synthase 2; CCL7, chemokine ligand 7; CCL20, CC motif chemokine ligand 20; CXCL2, C-X-C motif chemokine ligand 2; CCR2, CC motif chemokine receptor 2; CDC42, cell division DUSP2, dual specificity phosphatase 2; NAB2, NGFI-A binding protein 2; ATF3, activating transcription factor 3. ⇑ Corresponding author at: Center of Emphasis in Neurosciences, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Medica Building 3002, 5001 El Paso Drive, El Paso, TX 79905, USA. E-mail address: [email protected] (S.D. Gonzalez). Suzanne D. Gonzalez a,⇑, Aislinn J. Williams , Caren J. Blacker , Jennifer L. Vande Voort , Kathryn M. Schak , Charles B. Nemeroff , Alik S. Widge , Mauricio Tohen e,g